Kidney replacement therapy within 12 months of childbirth in Australia

Overview

Introduction

Pregnancy may unmask or worsen kidney disease, in some cases leading to postnatal kidney failure. Outcomes in these women remain poorly defined.

Methods

Using linked perinatal (1991–2013), hospital and Australia and New Zealand Dialysis and Transplant Registry (ANZDATA) (1970–2016) records from 4 Australian jurisdictions, we explored characteristics and outcomes among women who commenced kidney replacement therapy (KRT) within 12 months postchildbirth.

Results

Among 761 women who commenced KRT postchildbirth (N = 1196 babies), 44 started KRT within 12 months postchildbirth (n = 48 babies). Of these, 38 women began hemodialysis (HD), 4 began peritoneal dialysis (PD), and 2 received preemptive transplants. Median maternal age at childbirth was 29 years. The median time from childbirth to KRT initiation was 142 (interquartile range [IQR] 17–216) days, with one-third starting within 42 days postpartum. Among the HD group, 9 of 38 women (23.7%) transitioned to home dialysis within the first year. One-third of women died during follow-up (median: 13.7 years), with a median age at death of 31 (IQR: 28.5–36.1) years. Women who commenced HD died younger and sooner (median: 3.4 years postchildbirth, IQR: 2.8–7.1 years) than those who started on PD. Nearly 90% of babies were liveborn. Median gestational age was 34 (IQR: 31–37) weeks and birthweight was 2120 g (IQR: 1690–3090 g). Composite adverse pregnancy outcomes (≥ 1 of preterm birth, low birthweight, or hypertensive disorders) occurred in 75% of pregnancies.

Conclusion

Women commencing KRT within 12 months postchildbirth represents a high-risk group with complex medical needs. Maternal death during early childhood years is an underrecognized phenomenon and warrants further research.