Research

Registry-Embedded Clinical Trials

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SWIFTTEACH-PDRESOLVEBEST-Fluids

Registry-embedded clinical trials are designed within existing clinical registries, using real-world data to run faster, more efficient studies. By embedding research into routine care, these trials generate practical, scalable evidence to improve patient outcomes and make better use of the data already being collected.

The following Registry-embedded trials are collaborative projects with our partners Australiasian Kidney Trials Network (AKTN) and the National Health and Medical Research Council – Clinical Trials Centre (NHMRC-CTC). Find out more about our recent trials below.

TACKLE-IT (Treat ACute T-cell mediated rejection in Kidney and SPK transplant rEcIpienTs)

TACKLE-IT is a large, international registry-embedded clinical trial testing the optimal steroid regimen for treating acute T-cell mediated rejection in kidney and simultaneous pancreas–kidney transplant recipients.

Learn more about TACKLE-IT

SWIFT (Symptom Monitoring With Feedback Trial)

A novel registry-based cluster randomised controlled trial among Australian and New Zealand adults on haemodialysis to asess if symptom monitoring with feedback to nurses, kidney doctors and patients, improves health-related quality of life.

Learn more about SWIFT

Targeted Education ApproaCH to Improve Peritoneal Dialysis Outcomes Cluster Randomised Controlled Trial (TEACH-PD)

A pragmatic, multi-centre, multinational, cluster-randomised trial (CRCT), randomising PD units to implement TEACH-PD training modules targeted at PD trainers and incident PD patients versus standard existing practice.

Learn more about TEACH-PD

Randomised Evaluation of SOdium dialysate Levels on Vascular Events: A cluster clinical study

A pragmatic, cluster-randomised study designed to evaluate the effectiveness of dialysis units adopting a higher or lower default dialysate sodium concentration.

Learn more about RESOLVE

Better Evidence for Selecting Transplant Fluids (BEST-Fluids)

A pragmatic, registry-based, double-blind, randomised controlled trial evaluating the effect of Plasmalyte versus 0.9% saline on early kidney transplant function in deceased donor kidney transplantation.

Learn more about BEST-Fluids

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